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. 2022 Feb 24;8:78. doi: 10.1038/s41420-022-00879-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The ABR thresholds shift of all frequencies were increased after cisplatin administration in mice compared to the control group. B Cell counting and cochleogram there was a significant HCs loss in the cochlear basal turn of the cisplatin group compared to that of the control group, but no significant HCs loss was found in the apical and middle turns in the cisplatin group versus control group. C Representative immunostaining images showing that the fluorescence intensity of c-Myb was significantly downregulated after cisplatin administration compared with the control group. Scale bar = 20 μm. D Western blot showed that the protein level of c-Myb was significantly downregulated in the cisplatin group compared with the control group. n = 6 for each group. *p < 0.05, **p < 0.01, and ***p < 0.001.