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. 2022 Feb 24;8:78. doi: 10.1038/s41420-022-00879-9

Fig. 4. The upregulation of c-Myb expression reduces the level of ROS in cochlear HCs after cisplatin exposure.

Fig. 4

A Representative images of Mito-SOX Red staining showing the accumulation of ROS as indicated by the intensified immunostaining signals of Mito-SOX Red (red) in cultured HCs (myosin 7a, green). Scale bar (low magnification) = 20 μm. Scale bar (high magnification) = 5 μm. B A significant number of Mito-SOX/myosin 7a double-positive IHCs and OHCs were observed after cisplatin treatment for 48 h in vitro, while pretreatment with AAV-c-Myb significantly reduced the number of cisplatin-induced Mito-SOX Red/myosin 7a double-positive HCs in the cultured basal-turn cochlear HCs. ***p < 0.001, n = 6 for each group.