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. 2022 Feb 24;5:161. doi: 10.1038/s42003-022-03113-5

Table 5.

Tissue (ng/g)/serum (ng/mL) ratio for parent compound and O-demethyl metabolites.

Compound Time Brain/serum Liver/serum Kidney/serum
AMB-FUBINACA 15 min 4.38 0.56 3.27
30 min 6.05 1.52 5.42
180 min n.d. n.d. n.d.
O-demethyl AMB-FUBINACA 15 min n.d. 4.47 0.50
30 min 0.05 4.63 0.36
180 min n.d. 1.94 0.32
AMB-CHMICA 15 min 0.47 18.8 0.81
30 min 0.31 13.3 1.00
180 min n.d. 1.18 n.d.
O-demethyl AMB-CHMICA 15 min n.d. n.d. n.d.
30 min n.d. n.d. n.d.
180 min n.d. 15.0 n.d.

n.d.: Compound below the limit of detection in tissue and/or serum.