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. 2022 Feb 24;5:166. doi: 10.1038/s42003-022-03110-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Global profile of metabolites with dose-dependent changes, as assessed by log-linear regressions. b Global profile of metabolites with dose-independent changes, as assessed by two sample t-tests with Benjamini & Hochberg False Discovery Rate (FDR) adjustment. c Fold changes of selected metabolites, classified according to whether the metabolite changed in a dose-dependent (increasing/decreasing) or dose-independent manner. d Changes in adenine nucleotide/nucleoside pools. e Relative changes in the indicated metabolites. Raw data are available in Supplementary Data 1.