Table 2.
Multivariate logistic regression analysis on associated factors in ACS group.
| Variables | END (n = 36) | Non-END (n = 906) | OR | 95% CI | Adjusted P value |
|---|---|---|---|---|---|
| Age (year), median (IQR) | 63 (54–69) | 64 (56–72) | 0.974 | 0.941–1.007 | 0.125 |
| Gender (male), n (%) | 25 (69.4) | 615 (67.9) | 1.318 | 0.558–3.114 | 0.528 |
| Current smoker, n (%) | 12 (33.3) | 353 (39.0) | 0.582 | 0.234–1.444 | 0.243 |
| Current drinker, n (%) | 8 (22.2) | 210 (23.2) | 0.790 | 0.290–2.155 | 0.645 |
| Hypertension, n (%) | 22 (61.1) | 464 (48.8) | 1.843 | 0.864–3.931 | 0.114 |
| Diabetes mellitus, n (%) | 5 (13.9) | 148 (16.3) | 0.810 | 0.257–2.559 | 0.720 |
| Hyperlipidemia, n (%) | 0 (0.0) | 36 (4.0) | 0.000 | 0.000- | 0.998 |
| Coronary heart disease, n (%) | 5 (13.9) | 127 (14.0) | 0.784 | 0.277–2.221 | 0.647 |
| Atrial fibrillation, n (%) | 7 (19.4) | 93 (10.3) | 3.657 | 1.323–10.107 | 0.012 |
| History of stroke, n (%) | 5 (13.9) | 152 (16.8) | 0.749 | 0.273–2.059 | 0.576 |
| BMI (kg/m2), median (IQR) | 23.8 (20.8–26.7) | 23.8 (21.1–26.1) | 0.970 | 0.876–1.073 | 0.551 |
| SBP (mmHg), median (IQR) | 151 (131–165) | 151 (137–165) | 1.001 | 0.981–1.022 | 0.932 |
| DBP (mmHg), median (IQR) | 90 (79–99) | 88 (80–98) | 1.018 | 0.986–1.051 | 0.273 |
| OTT (min), median (IQR) | 169 (123–213) | 165 (125–206) | 1.002 | 0.996–1.009 | 0.456 |
| DNT (min), median (IQR) | 58 (39–84) | 54 (34–85) | 1.003 | 0.995–1.011 | 0.425 |
| Baseline NIHSS, median (IQR) | 6 (2–9) | 6 (3–11) | 0.947 | 0.884–1.015 | 0.124 |
| BG (mmol/L), median (IQR) | 6.74 (5.87–7.96) | 6.80 (5.80–8.61) | 0.984 | 0.860–1.126 | 0.814 |
| NLR at admission, median (IQR) | 2.02 (1.37–5.17) | 2.78 (1.80–4.63) | 0.938 | 0.813–1.081 | 0.376 |
| TOAST classification | 1.703 | 1.142–2.538 | 0.009 | ||
| LAA, n (%) | 24 (66.7) | 446 (49.2) | |||
| CE, n (%) | 4 (11.1) | 135 (14.9) | |||
| SAO, n (%) | 8 (22.2) | 253 (27.9) | |||
| ODC, n (%) | 0 (0.0) | 19 (2.1) | |||
| UND, n (%) | 0 (0.0) | 53 (5.8) |
ACS anterior circulation stroke, BG blood glucose, BMI body mass index, CE cardioembolism, DBP diastolic blood pressure, DNT door to needle time, END early neurological deterioration, IQR interquartile range, LAA large-artery atherosclerosis, NIHSS National Institute of Health Stroke Scale, NLR neutrophil-to-lymphocyte ratio, ODC stroke of other determined cause, OTT symptom onset to thrombolysis time, SAO small-artery occlusion, SBP systolic blood pressure, TOAST trial of Org 10,172 in acute stroke treatment, UND stroke of undetermined cause.