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. 2022 Feb 24;12:3173. doi: 10.1038/s41598-022-06970-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The 129 miRNA M/E sites that have significantly different editing levels in HD-PC samples when compared to healthy controls. (a) The categories of the 129 M/E sites. (b) The change of editing levels of 129 M/E sites in HD-PC samples compared to PC samples. (c) Then editing levels of six miRNA M/E sites that have significantly different editing levels in HD-PC samples when compared to PC samples. “***” indicate P-values smaller than 0.05, Mann-Whitney U-tests and corrected with the Benjamini and Hochberg method⁸⁵. (d) The MiRME map of hsa-mir-10b in one of the HD-PC samples (SRR1759254). (e) The MiRME map of hsa-mir-127 in one of the HD-PC samples (SRR1759256). (f) The MiRME map of hsa-mir-219a-2 in one of the Unknown samples (SRR1658356). (g-i) The details of hsa-mir-10b_26_A_c in SSR1759254, hsa-mir-127_79_G_a in SSR1759256 and hsa-mir-219a-2_83_U_a in SSR1658356, respectively. The edited nucleotide are shown in blue. And the first number on the right indicates the number of raw sequencing reads, the second number indicates the length of the reads, and the third number indicates the weight of the reads on this locus as calculated by the cross-mapping correction algorithm⁸⁴. (j) Comparisons of normalized expression levels (in TPTM) of hsa-mir-10b_26c, i.e., hsa-mir-10b-5p with additional cytosine at 5’ end, in the HD-PC and PC samples.