Table 2.

Adjusted^a Odds Ratios (ORs) of cases of dry eye disease with respect to regular exposure of contraceptives 1 year prior to index.

	Cases	Controls	Odds ratios	95% CI
Number of subjects	1,799	7,196
No use of HC (%)	60.42	74.47	1.00	Reference
bRegular use of HC (%)	10.01	4.70	2.73	2.21–3.73
Recent use (0–90 days)	4.45	2.00	2.79	2.05–3.74
Past use 91days+	5.56	2.70	2.70	2.06–3.54
cIrregular use of HC (%)	29.57	20.83	1.80	1.58–2.04
Risk with number of prescriptions
1–2 HC	16.84	12.73	1.66	1.42–1.94
3–4 HC	7.84	4.75	2.16	1.74–2.69
>4 HC	14.90	8.05	2.35	1.98–2.79

^aAdjusted for variables in Table 1.

^bRegular use of HCs was defined as at least 2 HCs prescriptions in first year prior to index, and at least 2 HCs prescriptions in the second year prior to index date. All HCs except for intrauterine levonorgestrel were included.

^cIrregular use included anyone who were not classified as regular users of HC. All HCs except for intrauterine levonorgestrel were included.