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. 2022 Feb 24;12:3143. doi: 10.1038/s41598-022-07236-x

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© The Author(s) 2022, corrected publication 2022

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Workflow of experimental and surgical procedures associated with creation of the model. (A) Workflow for iPRECIO pump programming prior to implantation on E18 and subsequent replacement of saline with Oxt by subcutaneous access of the refill port on E21. (B) Left to right: sequential surgical workflow for implantation of the pre-programmed iPRECIO pump followed by internal jugular vein cannulation with the pump catheter on E18. All surgical procedures were performed in strict accordance with institutional guidelines for rodent surgery, anesthesia, and analgesia.