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. 2022 Feb 24;12:3143. doi: 10.1038/s41598-022-07236-x

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Labor induction with oxytocin is not associated with oxidative stress in the developing brain. (A) From left to right: Labor induction with oxytocin was not associated with an increase in either glutathione, 4-hydroxynonenal, protein carbonyl, reactive oxygen/nitrogen species (ROS/RNS), or total antioxidant capacity in the developing fetal cortex. All data are presented per mg of brain protein. Fetal brains exposed to paraquat in utero served as positive control. (B) Expression of genes mediating oxidative stress or antioxidant defense were not significantly differentially expressed in the fetal cortex after labor induction with oxytocin. Collectively, these data indicate that labor induction with Oxt is unlikely to be associated with oxidative stress in the developing brain. Data were analyzed with Welch’s t-test and expressed as mean ± SEM (n = 5–8 per treatment condition with pups represented from all unique dams).