Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 24;13(2):178. doi: 10.1038/s41419-022-04635-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — (A) Family analysis of transcription factors based on the RNA sequencing data; (B) Spearman analysis was used to detect the correlations between PCLAF and E2F1 and PTTG1 in the neuroblastoma database; (C, D) Prediction of the sequence logo of E2F1 and the binding sites of E2F1 on the PTTG1 promoter region were predicted by JASPAR; (E) Graphical representation of enrichment for E2F1 on the regulatory regions of PTTG1 in HeLa, K562, and LM2 cells. Red boxes show regions with E2F1 enrichment; (F) The mRNA level of PTTG1 after decreasing E2F1 by siE2F1 in SK-N-BE (2) and SH-SY5Y cell lines; (G) The protein levels of PTTG1 after decreasing E2F1 by siE2F1 in SK-N-BE (2) and SH-SY5Y cell lines; (H) The mRNA level of E2F1 after decreasing PCLAF by siPCLAF in SK-N-BE (2) and SH-SY5Y cell lines.; (I) The protein levels of E2F1 after decreasing PCLAF by siPCLAF in SK-N-BE (2) and SH-SY5Y cell lines. (*p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001, and bar graphs represent the mean ± SEM).