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Binding affinity to afatinib in EGFR wild type (A) and p.L747P conformation (B) by hydrogen bond occupancy analysis. Binding affinity to osimertinib in EGFR wild type (C) and p.L747P conformation (D) by hydrogen bond occupancy analysis. Dynamics calculations for binding free energies with afatinib (E) and osimertinib (F) when substituting proline for leucine.
