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Kinase inhibition activity of diverse EGFR TKIs against p.L747P and EGFR WT cell lines.
| Compounds IC50 (nmol) | A431 WT | A431 p.L747P |
|---|---|---|
| Gefitinib | 724.8 | 147.3 |
| Erlotinib | 945.1 | 167.3 |
| Afatinib | 14.5 | 6.7 |
| Dacomitinib | 13.1 | 5.2 |
| Osimertinib | 341.6 | 80.9 |
| Poziotinib | 1.1 | 1.6 |
| Mobocertinib | 17.2 | 15.8 |
