FIGURE 5.

Transcriptome traits related to MHC-II signature in the ICI-cohort. (A,B). Gene Ontology enrichment (A) and KEGG enrichment analyses (B) show that gene sets up-regulated in MHC-H tumors were enriched in the immune activation process, while those overexpressed in MHC-L tumors were enriched in fatty acid metabolism and steroid hormone biosynthesis. The top ten genes per set are shown (ranked by single-gene p value, GO: red: high, blue: low; KEGG: orange: high, green: low). (C–H) The GSEA analysis shows the key pathways of enrichment in the MHC-H (up) and MHC-L (down) groups. Antigen processing and presentation (C), PD−1 signaling (D), immune cell activation (E), cytokine production (F), and IFN−gamma (G) related pathways were significantly up-regulated in the MHC-H group, while fatty acid metabolism and glucuronidation (H) were significantly up-regulated in the MHC-L group. The x-axis represents the ranking of genes in the rank lists.