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. 2022 Feb 11;13:790334. doi: 10.3389/fimmu.2022.790334

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Copyright © 2022 Miyara, Saichi, Sterlin, Anna, Marot, Mathian, Atif, Quentric, Mohr, Claër, Parizot, Dorgham, Yssel, Fadlallah, Chazal, Haroche, Luyt, Mayaux, Beurton, Benameur, Boutolleau, Burrel, de Alba, Mudumba, Hockett, Gunn, Charneau, Calvez, Marcelin, Combes, Demoule, Amoura and Gorochov

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Beta-HCoV-primed individuals mount IgG-dominated anti-SARS-CoV-2 responses. (A) Heatmap representation of the IgG, IgA, IgM anti-SARS-CoV-2 virus components (S1, S1S2, RBD, NC) titres (columns) for the entire cohort of patients (rows). Patients were labelled according to their corresponding severity state (moderate, severe, critical) and time point of antibody measurement. (B) Pairwise correlation heatmap of the corresponding IgM, IgG and IgA titres in all COVID-19 patients. The Pearson correlation coefficient is colour-coded. The vertical lines separate SARS-CoV-2 and anti-alpha and beta-HCoV Ig-related titres.