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. 2022 Jan 10;13(4):1095–1120. doi: 10.1016/j.jcmgh.2022.01.002

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Chronic COX2 inhibition reduces macrophage expression of efferocytosis-specific genes. BL6 BMDMs were treated with vehicle (WT) or the COX2 inhibitor SC236 from isolation. On day 8, BMDMs were polarized with either 20 ng/mL IL-10 (IL-10) or 100 ng/mL LPS (100 LPS). (A–J) Expression of efferocytosis-specific genes on day 10 of culture was determined by qPCR. Data are presented as fold change compared with WT COX2 + 100 ng/mL LPS. (K) Summary of efferocytosis specific proteins whose associated gene expression was investigated by qPCR. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. Two-way analysis of variance with Tukey's multiple comparisons test and adjusted P values. ns, not significant.