TABLE 1.

The therapeutic index of CPP-BoNTA proteins.

Samples	IMLD50 (ng/kg)	Units (= ng)	IMED50 (ng/kg)	IMED50 (U/kg)	Therapeutic index IMLD50 (ng/kg)/IMED50 (ng/kg)
Botox	3.41	0.068	0.12	1.77	28
WT-BoNTA	79.85	1.60	2.20	1.38	36
TAT-BoNTA	26.48	0.53	0.22	0.42	120
Pep1-BoNTA	34.89	0.70	0.37	0.53	94
ZFP3-BoNTA	98.97	1.98	0.70	0.35	142
BoNTA- ZFP3	168.61	3.37	0.89	0.26	189
ZFP3-BoNTA -ZFP3	780.89	15.62	2.77	0.18	282

Note: In the present study, the active unit (U) of Botox is re-defined as described in the Materials and Methods. One unit of BoNTA, sample is defined as the amount of proteins that, when intramuscularly injected into each mouse, result in 50% death.