Table 1.
FoxP3 and HPV expression in OSCC and its association with clinicopathological indicators
| Variable | FoxP3 low | FoxP3 high | p‐value | HPV negative | HPV positive | p‐value | |
|---|---|---|---|---|---|---|---|
| N | n = 106 | 37 (35) | 69 (65) | 41 (39) | 65 (61) | ||
| Age, years (SD) | 62.7 ± 16.1 | 60.6 ± 15.7 | 63.8 ± 16.2 | 0.34 | 63.0 ± 16.8 | 62.5 ± 15.7 | 0.89 |
| Gender | |||||||
| Male | 59 (56) | 21 (57) | 38 (55) | 1.00 | 22 (54) | 37 (57) | 0.84 |
| Female | 47 (44) | 16 (43) | 31 (45) | 19 (46) | 28 (43) | ||
| Location | |||||||
| Tongue | 53 (50) | 18 (49) | 35 (51) | 0.65 | 18 (44) | 35 (54) | 0.05* |
| Gingiva | 44 (42) | 17 (46) | 27 (39) | 16 (39) | 28 (43) | ||
| Others (lip, buccal, oral floor) | 9 (8) | 2 (5) | 7 (10) | 7 (17) | 2 (3) | ||
| Stage | |||||||
| I | 14 (13) | 5 (13) | 9 (13) | 0.93 | 6 (15) | 8 (12) | 0.82 |
| II | 25 (24) | 10 (27) | 15 (22) | 10 (24) | 15 (23) | ||
| III | 41 (39) | 14 (38) | 27 (39) | 17 (41) | 24 (37) | ||
| IV | 26 (25) | 8 (22) | 18 (26) | 8 (20) | 18 (28) | ||
| T classification | |||||||
| 1 | 16 (15) | 6 (16) | 10 (14) | 0.95 | 6 (15) | 10 (15) | 0.72 |
| 2 | 37 (35) | 14 (38) | 23 (33) | 17 (41) | 20 (31) | ||
| 3 | 28 (26) | 9 (24) | 19 (28) | 10 (24) | 18 (28) | ||
| 4 | 25 (24) | 8 (22) | 17 (25) | 8 (20) | 17 (26) | ||
| N classification | |||||||
| 0 | 65 (61) | 27 (73) | 38 (55) | 0.09 | 25 (61) | 40 (62) | 1.00 |
| 1‐3 | 41 (39) | 10 (27) | 31 (45) | 16 (39) | 25 (38) | ||
| M classification | |||||||
| 0 | 105 (99) | 36 (97) | 69 (100) | 0.35 | 40 (98) | 65 (100) | 0.39 |
| 1 | 1 (1) | 1 (3) | 0 (0) | 1 (2) | 0 (0) | ||
| Tumor grade | |||||||
| Well | 47 (44) | 13 (35) | 34 (49) | 0.24 | 19 (46) | 28 (43) | 0.76 |
| Mod | 45 (42) | 20 (54) | 25 (36) | 18 (44) | 27 (42) | ||
| Poor | 14 (13) | 4 (11) | 10 (15) | 4 (10) | 10 (15) | ||
| Treatment | |||||||
| None | 1 (1) | 0 (0) | 1 (1) | 0.38 | 0 (0) | 1 (2) | 0.71 |
| Surgery | 13 (12) | 6 (16) | 7 (10) | 6 (15) | 7 (11) | ||
| Chemotherapy+radiotherapy | 33 (31) | 14 (38) | 19 (28) | 14 (34) | 19 (29) | ||
| Surgery+radiotherapy+chemotherapy | 59 (56) | 17 (46) | 42 (61) | 21 (51) | 38 (58) | ||
| FOX‐P3 | |||||||
| Low | 37 (35) | 0 (0) | 16 (39) | 23 (35) | 1.00 | ||
| High | 0 (0) | 69 (65) | 25 (61) | 42 (65) | |||
| HPV | |||||||
| Negative | 14 (38) | 27 (39) | 1.00 | 41 (39) | 0 (0) | ||
| Positive | 23 (62) | 42 (61) | 0 (0) | 65 (61) | |||
Note: p‐value by Student's t‐test or Wilcoxon's rank sum test for continuous variables and Fisher's exact test for categorical variables. ( ), the ratio of event (%).
*denotes a number that was significant in the statistical analysis.