FIGURE 4.

Antiviral response of the ISR during viral infection. PERK-eIF2α signaling suppresses viral replication through inducing IFN-I production and eIF2α phosphorylation-mediated translation attenuation with TGEV infection (orange color). PFV infection inhibits viral replication through PERK-mediated autophagy (green color). In addition, viral infection induces SGs formation through PKR-eIF2α phosphorylation and plays antiviral response, such as MNV, EV71, RSV, VV, TBEV, SINV, HIV, MeV, Adenovirus, HCV, EMCV, NDV, PV and SeV (red color). GCN2-eIF2α signaling inhibit viral replication upon SINV infection (blue color).