Table 2.
Results of the unconditional association analysis and fixed effect meta-analysis of the two amino acids in HLA-DQβ1 protein that explain the association in the MHC class II region, HLA-DQβ1Leu26, and HLA DQβ1Pro55 and alternatives HLA-DQβ1Tyr26 and HLA DQβ1Ala71 in the European and African ancestry populations
| Amino acid position | Effect allele/non effect allele |
European ancestry population (N = 1,600) |
African ancestry population (N = 1,869) |
p valueMeta | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Frequency effect allele |
OR (95% CI) | p value |
Frequency effect allele |
OR (95% CI) | p value | |||||
| Clearance (n = 594) | Persistence (n = 1,006) | Clearance (n = 340) | Persistence (n = 1,529) | |||||||
| 26∗ | L/G,Y | 0.45 | 0.55 | 0.64 (0.54–0.75) | 8.63 × 10−8 | 0.35 | 0.49 | 0.55 (0.45–0.68) | 2.61 × 10−8 | 1.25 × 10−14 |
| 26 | L,Y/G | 0.77 | 0.78 | 0.92 (0.76–1.11) | 3.96 × 10−1 | 0.67 | 0.7 | 0.86 (0.7–1.07) | 1.89 × 10−1 | 1.29 × 10−1 |
| 26∗ | Y/G,L | 0.31 | 0.23 | 1.64 (1.36–1.98) | 1.62 × 10−7 | 0.32 | 0.21 | 1.81 (1.45–2.27) | 1.81 × 10−7 | 1.47 × 10−13 |
| 55 | L/R,P | 0.09 | 0.14 | 0.59 (0.45–0.79) | 3.04 × 10−4 | 0.07 | 0.08 | 0.82 (0.56–1.21) | 3.20 × 10−1 | 9.00 × 10−4 |
| 55∗ | L,P/R | 0.56 | 0.52 | 1.25 (1.07–1.48) | 6.10 × 10−3 | 0.43 | 0.36 | 1.42 (1.16–1.74) | 7.57 × 10−4 | 1.69 × 10−5 |
| 55∗ | P/R,L | 0.47 | 0.38 | 1.51 (1.28–1.77) | 8.79 × 10−7 | 0.36 | 0.27 | 1.6 (1.29–1.99) | 2.11 × 10−5 | 8.23 × 10−11 |
| 71 | D,K,T/A | 0.83 | 0.86 | 0.76 (0.61–0.95) | 1.73 × 10−2 | 0.76 | 0.8 | 0.81 (0.64–1.02) | 7.67 × 10−2 | 3.23 × 10−3 |
| 71 | K/A,D,T | 0.09 | 0.14 | 0.59 (0.44–0.79) | 3.43 × 10−4 | 0.07 | 0.08 | 0.82 (0.56–1.2) | 3.17 × 10−1 | 1.00 × 10−3 |
| 71 | T/A,D,K | 0.67 | 0.64 | 1.06 (0.88–1.27) | 5.49 × 10−1 | 0.6 | 0.61 | 0.9 (0.73–1.12) | 3.47 × 10−1 | 8.33 × 10−1 |
| 71 | D/A,K,T | 0.03 | 0.03 | 0.92 (0.58–1.46) | 7.21 × 10−1 | 0.09 | 0.08 | 1 (0.7–1.43) | 9.98 × 10−1 | 7.96 × 10−1 |
∗Asterisk indicates the amino acids significantly associated in the fixed-effect unconditional meta-analyses. Single letter and three letter amino acid code: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; T, Thr; S, Ser; Y, Tyr; V, Val; W, Trp.