Table 3.
Binding and thermodynamic parameters of [Pd(bpy)(proli-dtc)]NO3 complex with CT-DNA and BSA obtained from fluorescence emission experiments at various temperatures
| Experiments | T (K) | Ksv × 104 (M−1) | kq × 1012 (M−1 s−1) | Kb (M−1) | n | ΔGº (kcal/mol) | ΔHº (kcal/mol) | ΔSº (kcal/mol) |
|---|---|---|---|---|---|---|---|---|
| DNA binding | 293 | 1.51 ± 0.03 | 1.51 ± 0.03 | (2.43 ± 0.05) × 105 | 1.26 ± 0.01 | − 7.28 ± 0.06 | ||
| 300 | 1.28 ± 0.03 | 1.28 ± 0.03 | (3.08 ± 0.04) × 105 | 1.28 ± 0.01 | − 7.66 ± 0.06 | 8.54 ± 0.08 | 0.05 ± 0.001 | |
| 310 | 1.17 ± 0.02 | 1.17 ± 0.02 | (5.37 ± 0.05) × 105 | 1.35 ± 0.02 | − 8.20 ± 0.05 | |||
| BSA binding | 293 | 3.62 ± 0.02 | 3.62 ± 0.02 | (6.91 ± 0.03) × 103 | 0.85 ± 0.03 | − 5.16 ± 0.05 | ||
| 300 | 4.12 ± 0.04 | 4.12 ± 0.04 | (2.90 ± 0.03) × 103 | 0.76 ± 0.02 | − 4.74 ± 0.06 | − 22.59 ± 0.05 | − 0.06 ± 0.001 | |
| 310 | 4.20 ± 0.03 | 4.20 ± 0.03 | (0.82 ± 0.03) × 103 | 0.64 ± 0.02 | − 4.14 ± 0.06 |
All results were expressed as the mean ± standard deviation of three independent experiments