Table 3.
Distribution of mutations in the TERT gene promoter according to clinicopathological features.
| Parameter | Overall | C228T | C250T | A161C | G149T | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| + | − | + | − | + | − | + | − | + | − | |
| Gender | ||||||||||
| Male | 42 | 26 | 33 | 35 | 7 | 61 | 1 | 67 | 1 | 67 |
| Female | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 2 | 0 | 2 |
| p-value | 0.751 | |||||||||
| Age | ||||||||||
| <50 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
| 50–70 | 28 | 16 | 24 | 20 | 3 | 41 | 0 | 44 | 1 | 43 |
| >70 | 14 | 11 | 9 | 16 | 4 | 21 | 1 | 24 | 0 | 25 |
| p-value | 0.154 | |||||||||
| Smoking | ||||||||||
| Yes | 18 | 10 | 16 | 12 | 1 | 27 | 0 | 28 | 1 | 27 |
| No | 25 | 17 | 18 | 24 | 6 | 36 | 1 | 41 | 0 | 42 |
| p-value | 0.941 | |||||||||
| Tumor stage | ||||||||||
| ≤PT1 | 31 | 21 | 23 | 29 | 6 | 46 | 1 | 51 | 1 | 51 |
| >PT1 | 12 | 6 | 11 | 7 | 1 | 17 | 0 | 18 | 0 | 18 |
| p-value | 0.860 | |||||||||
| Tumor grade | ||||||||||
| LG | 15 | 12 | 11 | 16 | 2 | 25 | 1 | 26 | 1 | 26 |
| HG | 28 | 15 | 23 | 20 | 5 | 38 | 0 | 43 | 0 | 43 |
| p-value | 0.538 | |||||||||
| Tumor recurrence | ||||||||||
| Yes | 7 | 5 | 6 | 6 | 1 | 11 | 0 | 12 | 0 | 12 |
| No | 24 | 16 | 17 | 23 | 5 | 35 | 1 | 39 | 1 | 39 |
| p-value | 0.647 | |||||||||
| Tumor progression | ||||||||||
| Yes | 1 | 4 | 1 | 4 | 0 | 5 | 0 | 5 | 0 | 5 |
| No | 30 | 17 | 22 | 25 | 6 | 41 | 1 | 46 | 1 | 46 |
| p-value | 0.083 | |||||||||