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. 2022 Feb 11;13:803445. doi: 10.3389/fphys.2022.803445

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Copyright © 2022 Hu, Peng, Du, Zhang, Zhai, Xiong and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppression of miR-122-5p improves HFD-induced oxidative stress injury in fatty liver disease. (A) HFD-fed mice were injected with lentivirus encoding miR-122-5p antisense (miR-122-5p inhibitor) or nonsense (NC inhibitor) for 4 weeks, then the liver weight was measured. (B) Hepatic TC and TG. (C) Liver morphological characteristics were observed by H&E and Oli Red O staining after injected with miR-122-5p or NC inhibitor. (D) RT-qPCR analyzed the expression of TNF-α, IL-6, and IL-8. (E) ELISA analyzed the level of TNF-α, IL-6, and IL-8 in liver tissue. (F) The activity of SOD and GSH-Px, and the content of MDA. (G) Western blot analysis of PI3K, AKT, p-AKT, mTOR, and p-mTOR expression. Error bars indicate SD. *P < 0.05, ^**P < 0.01, ^***P < 0.001.