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. 2022 Feb 24;9(3):e1149. doi: 10.1212/NXI.0000000000001149

Figure 4. Whole Blood Transcriptome Reveals Neutrophil Activation in Patients With NMOSD.

Figure 4

(A) Principal component analysis indicating transcriptional clustering in whole blood of healthy control subjects (n = 18) and patients with AQP4 antibody–positive NMOSD (n = 26). (B) Visualization of networks between the gene ontology (GO) biological process in AQP4 antibody–positive NMOSD whole blood RNA-seq. GO analysis based on GAGE was performed in healthy controls (n = 18) and patients with AQP4 antibody–positive NMOSD (n = 26). (C) The top 10 GO terms associated with biological process in AQP4 antibody–positive NMOSD whole blood RNA-seq. HC = healthy control.