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. 2022 Feb 13;23(4):2065. doi: 10.3390/ijms23042065

Figure 4.

Figure 4

Effects of CN on HMGB1-induced permeability in vitro and in vivo. The effects of CN on: (A) LPS-induced hyperpermeability in HUVECs (100 ng/mL); (B) HMGB1-induced hyperpermeability in HUVECs (1 μg/mL); (C) CLP-induced hyperpermeability in mice (n = 5/each group); (D) the effects of CN on the HMGB1-mediated phosphorylation of p38 were determined using an ELISA (upper image) or Western blotting (lower image). Data are expressed as the mean ± SD values of three independent experiments on different days. * p < 0.05 versus group treated with LPS (A) or HMGB1 (B–D).