LOAD |
Late-onset Alzheimer’s disease |
AD |
Alzheimer’s disease |
Aβ |
β-amyloid peptides |
PAI-1 |
Plasminogen activator inhibitor 1 |
RS |
Replicative senescence |
SIPS |
Stress-induced premature senescence |
SASP |
Senescence-associated secretory phenotype |
SA-β-gal |
Senescence-associated β-galactosidase |
pRb |
Phosphorylated retinoblastoma protein |
SAHFs |
Senescence-associated heterochromatin foci |
SDFs |
Senescence-associated DNA damage foci |
mH2A |
MacroH2A |
HSCs |
Hematopoietic stem cells |
NFTs |
Neurofibrillary tangles |
MCI |
Mild cognitive impairment |
LTL |
Leukocyte telomere length |
APP |
Amyloid precursor protein |
PS1 |
Presenilin 1 |
OPCs |
Oligodendrocyte precursor cells |
HMGB1 |
High-mobility group box 1 |
TERT |
Telomerase reverse transcriptase |
TERC |
Telomerase RNA component |
ATM |
Ataxia-telangiectasia mutated |
FAD |
Familial AD |
VEGF-1 |
Vascular endothelial growth factor 1 |
NSPCs |
Neural stem/progenitor cells |
ROS |
Reactive oxygen species |
NLRP3 |
NLR family pyrin domain containing 3 |
DAM |
Disease-associated microglia |
tPA |
Tissue-type plasminogen activator |
uPA |
Urokinase-type plasminogen activator inhibitor |
ATII |
Alveolar type II cells |
TGF-β1 |
Transforming growth factor β1 |
NSC |
Neuronal stem cell |