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. 2022 Feb 18;23(4):2279. doi: 10.3390/ijms23042279

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Validation of the clinical relevance of KCNQ1-coexpressed genes and the PPI. Kaplan–Meier survival analysis representing the probability of overall survival based on low/high expression of DBF4 zinc finger (DBF4) (A), cyclin A2 (CCNA2) (B), cyclin B1 (CCNB1) (C), minichromosome maintenance complex component 6 (MCM6) (D), cell division cycle 45 (CDC45) (E), checkpoint kinase 1 (CHEK1) (F), and cell division cycle 6 (CDC6) (G). PPI of KCNQ1 and the seven coexpression genes demonstrating that enriched functions mainly participate in DNA replication, cell cycle G1/S phase transition, cell cycle G2/M phase transition, and double-strand break repair (H).