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. 2022 Feb 9;14(2):354. doi: 10.3390/v14020354

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthesis of diphyllin 1. Reagents and conditions: (a) K₂CO₃, CH₃CN, N₂, 90 °C, 24 h, 94%; (b) p-TsOH, dry-benzene, reflux, 10 h, 100%; (c) n-BuLi, dry-THF, N₂, −78 °C for 2 h and rt, 3 h, 89%; (d) MnO₂, CH₂Cl₂, N₂, rt, 16 h, 93%; (e) LiHMDS, dry-THF, N₂, −65 °C, 48 h, 26%; (f) HgO, HgCl₂, dry-CH₃CN, reflux, 5 h, 44%; (g) p-TsOH, benzene, reflux, 15 h, 70%.