Table 4.
List of GO terms enriched with colonic DEGs (padj < 0.05).
| Category | GO ID | Description | Gene Name | Count | Up | Down | padj |
|---|---|---|---|---|---|---|---|
| BP | GO:0006805 | xenobiotic metabolic process | Acaa1b↑Cyp2c66↑Ugt1a1↑Lpo↑Cyp2c65↑Cyp2c55↑Nceh1↑Ugt1a7c↑Cyp2d12↓Cyp2d9↓Srd5a2↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 14 | 8 | 6 | 1.06 × 10−8 |
| BP | GO:0042737 | drug catabolic process | Cyp2c66↑Cyp2c65↑Akr1c18↑Cyp4b1↑Adh5↑Cyp2c55↑Cubn↑Aldh3b1↑Cyp2d12↓Cyp2d9↓Adh1↓Cyp2c68↓Nt5e↓Cyp2c69↓Cyp2f2↓ | 15 | 8 | 7 | 1.79 × 10−7 |
| BP | GO:0042738 | exogenous drug catabolic process | Cyp2c66↑Cyp2c65↑Cyp4b1↑Cyp2c55↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 9 | 4 | 5 | 1.79 × 10−7 |
| BP | GO:0006690 | icosanoid metabolic process | Cyp2c66↑Cyp2c65↑Akr1c18↑Cyp2c55↑Tlr2↑Ggt1↑Cyp2d12↓Cyp2d9↓Pla2g4f↓Cyp2c68↓Pla2g5↓Cyp2c69↓Cyp2f2↓ | 13 | 6 | 7 | 1.79 × 10−7 |
| BP | GO:0006631 | fatty acid metabolic process | Acaa1b↑Ces1f↑Ppara↑Cyp2c66↑Lpin2↑Ces1d↑Pdk4↑Acsf2↑Cyp2c65↑Akr1c18↑Lpl↑Cyp2c55↑Slc27a4↑Ggt1↑Ehhadh↑Abhd3↑Adipoq↑Cyp2d12↓Cyp2d9↓Pla2g4f↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 23 | 17 | 6 | 3.37 × 10−7 |
| BP | GO:0016042 | lipid catabolic process | Acaa1b↑Ces1f↑Lpin2↑Ces1d↑Akr1c18↑Lpl↑Ces1g↑Aspg↑Nceh1↑Slc27a4↑Ugt1a7c↑Ehhadh↑Abhd3↑Adipoq↑Pla2g4f↓Srd5a2↓Pla2g2a↓Pla2g5↓Ces3a↓Hexb↓ | 20 | 14 | 6 | 7.85 × 10−7 |
| BP | GO:1901568 | fatty acid derivative metabolic process | Cyp2c66↑Cyp2c65↑Akr1c18↑Cyp2c55↑Tlr2↑Ggt1↑Cyp2d12↓Cyp2d9↓Pla2g4f↓Cyp2c68↓Pla2g5↓Cyp2c69↓Cyp2f2↓ | 13 | 6 | 7 | 2.80 × 10−6 |
| BP | GO:0046394 | carboxylic acid biosynthetic process | Gapdh↑Hkdc1↑Ppara↑Pdk4↑Akr1c18↑Nags↑Lpl↑Malrd1↑Aldh1a1↑Ggt1↑Abhd3↑Ugdh↑Tkfc↑Gpd1↑Rdh16↓Eno3↓Pla2g4f↓Hif1a↓Hk2↓Rdh9↓Pla2g5↓ | 21 | 14 | 7 | 2.80 × 10−6 |
| BP | GO:0016053 | organic acid biosynthetic process | Gapdh↑Hkdc1↑Ppara↑Pdk4↑Akr1c18↑Nags↑Lpl↑Malrd1↑Aldh1a1↑Ggt1↑Abhd3↑Ugdh↑Tkfc↑Gpd1↑Rdh16↓Eno3↓Pla2g4f↓Hif1a↓Hk2↓Rdh9↓Pla2g5↓ | 21 | 14 | 7 | 2.80 × 10−6 |
| BP | GO:0071466 | cellular response to xenobiotic stimulus | Acaa1b↑Cyp2c66↑Ugt1a1↑Lpo↑Cyp2c65↑Cyp2c55↑Nceh1↑Ugt1a7c↑Cyp2d12↓Cyp2d9↓Srd5a2↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 14 | 8 | 6 | 2.80 × 10−6 |
| MF | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Cyp2c66↑Cyp2c65↑Cyp2d26↑Cyp4b1↑Cyp3a44↑Cyp2c55↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 11 | 6 | 5 | 2.77 × 10−9 |
| MF | GO:0004497 | monooxygenase activity | Tph1↑Fmo5↑Cyp2c66↑Cyp2c65↑Cyp2d26↑Akr1c18↑Cyp4b1↑Cyp3a44↑Cyp2c55↑Akr1c19↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 15 | 10 | 5 | 2.02 × 10−8 |
| MF | GO:0008395 | steroid hydroxylase activity | Cyp2c66↑Cyp2c65↑Cyp3a44↑Cyp2c55↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 9 | 4 | 5 | 8.37 × 10−7 |
| MF | GO:0052689 | carboxylic ester hydrolase activity | Ces1f↑Ces1d↑Ces2b↑Car1↑Lpl↑Ces1g↑Aspg↑Nceh1↑Abhd3↑Bche↑Pla2g4f↓Pla2g2a↓Pla2g5↓Ces3a↓ | 14 | 10 | 4 | 8.37 × 10−7 |
| MF | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | Tph1↑Fmo5↑Cyp2c66↑Cyp2c65↑Cyp2d26↑Akr1c18↑Cyp4b1↑Cyp3a44↑Cyp2c55↑Akr1c19↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 15 | 10 | 5 | 2.51 × 10−6 |
| MF | GO:0008392 | arachidonic acid epoxygenase activity | Cyp2c66↑Cyp2c65↑Cyp2c55↑Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 6 | 3 | 3 | 5.79 × 10−6 |
| MF | GO:0008391 | arachidonic acid monooxygenase activity | Cyp2c66↑Cyp2c65↑Cyp2c55↑Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 6 | 3 | 3 | 1.12 × 10−5 |
| MF | GO:0046906 | tetrapyrrole binding | Cyp2c66↑Lpo↑Cyp2c65↑Cyp2d26↑Cyp4b1↑Cyp3a44↑Cyp2c55↑Cubn↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 13 | 8 | 5 | 1.56 × 10−5 |
| MF | GO:0005506 | iron ion binding | Tph1↑Cyp2c66↑Cyp2c65↑Cyp2d26↑Cyp4b1↑Cyp3a44↑Cyp2c55↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Nt5e↓Cyp2c69↓Cyp2f2↓ | 13 | 7 | 6 | 4.05 × 10−5 |
| MF | GO:0020037 | heme binding | Cyp2c66↑Lpo↑Cyp2c65↑Cyp2d26↑Cyp4b1↑Cyp3a44↑Cyp2c55↑Cyp2d12↓Cyp2d9↓Cyp2c68↓Cyp2c69↓Cyp2f2↓ | 12 | 7 | 5 | 4.27 × 10−5 |
| ↑upregulation | |||||||
| ↓downregulation | |||||||