Table 5.
List of pathways enriched with colonic DEGs (padj < 0.05).
| KEGG ID | Description | Gene Name | Count | Up | Down | padj |
|---|---|---|---|---|---|---|
| mmu00830 | Retinol metabolism | Ugt2b5↑Cyp2c66↑Ugt1a1↑Cyp2c65↑Cyp3a44↑Aldh1a1↑Ugt2b36↑Adh5↑Cyp2c55↑Gm15368↑Ugt1a7c↑Rdh16↓Adh1↓Cyp2c68↓Rdh9↓ | 15 | 11 | 4 | 1.76 × 10−10 |
| mmu00140 | Steroid hormone biosynthesis | Ugt2b5↑Cyp2c66↑Ugt1a1↑Cyp2c65↑Cyp2d26↑Akr1c18↑Cyp3a44↑Ugt2b36↑Cyp2c55↑Gm15368↑Ugt1a7c↑Cyp2d12↓Cyp2d9↓Srd5a2↓Cyp2c68↓ | 15 | 11 | 4 | 1.99 × 10−10 |
| mmu05204 | Chemical carcinogenesis | Ugt2b5↑Cyp2c66↑Ugt1a1↑Cyp2c65↑Cyp3a44↑Ugt2b36↑Adh5↑Cyp2c55↑Gm15368↑Ugt1a7c↑Aldh3b1↑Adh1↓Cyp2c68↓ | 13 | 11 | 2 | 4.60 × 10−7 |
| mmu00591 | Linoleic acid metabolism | Cyp2c66↑Cyp2c65↑Cyp3a44↑Cyp2c55↑Pla2g4f↓Cyp2c68↓Pla2g2a↓Pla2g5↓ | 8 | 4 | 4 | 1.34 × 10−5 |
| mmu04976 | Bile secretion | Ugt2b5↑Ugt1a1↑Slc51a↑Slc10a2↑Sct↑Ugt2b36↑Gm15368↑Nceh1↑Ugt1a7c↑Adcy9↑ | 10 | 10 | 0 | 0.000109402 |
| mmu00053 | Ascorbate and aldarate metabolism | Ugt2b5↑Ugt1a1↑Ugt2b36↑Gm15368↑Ugt1a7c↑Ugdh↑ | 6 | 6 | 0 | 0.000126403 |
| mmu00982 | Drug metabolism - cytochrome P450 | Ugt2b5↑Fmo5↑Ugt1a1↑Ugt2b36↑Adh5↑Gm15368↑Ugt1a7c↑Aldh3b1↑Adh1↓ | 9 | 8 | 1 | 0.000135848 |
| mmu00980 | Metabolism of xenobiotics by cytochrome P450 | Ugt2b5↑Ugt1a1↑Ugt2b36↑Adh5↑Gm15368↑Ugt1a7c↑Aldh3b1↑Adh1↓Cyp2f2↓ | 9 | 7 | 2 | 0.000182884 |
| mmu04726 | Serotonergic synapse | Tph1↑Cyp2c66↑Cyp2c65↑Cyp2d26↑Slc18a1↑Cyp2c55↑Cyp2d12↓Cyp2d9↓Pla2g4f↓Cyp2c68↓Htr4↓ | 11 | 6 | 5 | 0.000408708 |
| mmu00590 | Arachidonic acid metabolism | Cyp2c66↑Cyp2c65↑Cyp2c55↑Ggt1↑Pla2g4f↓Cyp2c68↓Pla2g2a↓Pla2g5↓ | 8 | 4 | 4 | 0.001096684 |
| mmu00040 | Pentose and glucuronate interconversions | Ugt2b5↑Ugt1a1↑Ugt2b36↑Gm15368↑Ugt1a7c↑Ugdh↑ | 6 | 6 | 0 | 0.001096684 |
| mmu00983 | Drug metabolism - other enzymes | Ces1f↑Ugt2b5↑Ugt1a1↑Ces1d↑Ces2b↑Ugt2b36↑Gm15368↑Ugt1a7c↑Gm45727↑ | 9 | 9 | 0 | 0.0021122 |
| mmu03320 | PPAR signaling pathway | Acaa1b↑Ppara↑Lpl↑Angptl4↑Hmgcs2↑Slc27a4↑Ehhadh↑Adipoq↑ | 8 | 8 | 0 | 0.002234301 |
| mmu00860 | Porphyrin and chlorophyll metabolism | Ugt2b5↑Ugt1a1↑Ugt2b36↑Gm15368↑Ugt1a7c↑ | 5 | 5 | 0 | 0.008876674 |
| mmu00010 | Glycolysis / Gluconeogenesis | Hkdc1↑Adh5↑Pgm2↑Aldh3b1↑Eno3↓Adh1↓Hk2↓ | 7 | 4 | 3 | 0.008876674 |
| mmu00592 | alpha-Linolenic acid metabolism | Acaa1b↑Pla2g4f↓Pla2g2a↓Pla2g5↓ | 4 | 1 | 3 | 0.01005902 |
| mmu00500 | Starch and sucrose metabolism | Hkdc1↑Sis↑Pgm2↑Hk2↓ | 4 | 3 | 1 | 0.030913453 |
| mmu00520 | Amino sugar and nucleotide sugar metabolism | Hkdc1↑Pgm2↑Ugdh↑Hk2↓Hexb↓ | 5 | 3 | 2 | 0.036511025 |
| mmu00052 | Galactose metabolism | Hkdc1↑Sis↑Pgm2↑Hk2↓ | 4 | 3 | 1 | 0.041823524 |
| ↑upregulation | ||||||
| ↓downregulation | ||||||