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Schematic illustration of the chemical structure and corresponding release mechanisms of TK-based ROS-responsive nanosystems, where TK is used as (a) linker to attach drugs to the surface of nanoparticles, (b) linkage to form prodrug-based NPs, (c) linker to form polyprodrug-based NPs with drug molecules attached to the same polymer unit by TK linkages or (d) linker to form encapsulated polyprodrugs based on multiple drug molecules attached to each other via TK bridges.
