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. 2022 Feb 12;23(4):2043. doi: 10.3390/ijms23042043

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cry increases glial Myc protein levels in physiological and GB conditions. (A–D) Confocal microscopy images of brains from 7-day-old adult flies with the following genotypes: (A) repo-Gal4 > UAS-LacZ (Control), (B) repo-Gal4 > UAS-cry (Cry), (C) repo-Gal4 > UAS-dmyc (Myc) and (D) repo-Gal4 > UAS-dmyc, UAS-cry (MycCry) with Myc marked in magenta (anti-Myc). (A’–D’) Glial nuclei marked in green (anti-Repo) (scale bar, 25 µm). (E) Glial Myc quantification and statistical analysis for at least n = 9 per genotype (ANOVA, post-hoc Bonferroni). (F–J) Confocal microscopy images of brains 7-day-old adult flies from (F) repo-Gal4 > UAS-LacZ (Control), (G) repo-Gal4 > UAS-cryRNAi (CryRNAi), (H) repo-Gal4 > UAS-dEGFR^λ, UAS-dp110 ^CAAX, UAS-cryRNAi (Glioma CryRNAi), (I) repo-Gal4 > UAS-dEGFR^λ, UAS-dp110 ^CAAX (Glioma) and (J) repo-Gal4 > UAS-cry (Cry); Myc is marked in magenta (anti-Myc) (F’–J’) and glial nuclei are marked in green (anti-Repo) (scale bar, 25 µm). (K) Glial Myc quantification and statistical analysis for at least n = 12 per genotype (ANOVA, post-hoc Bonferroni) ( n.s. not significant, ** p-value < 0.01, *** p-value <0.001).