Table 2.
Biological effects of S. rebaudiana derivatives in breast cancer models.
| Cell Line/Model | Compound | Effect (Cell Viability Assay) |
Reference |
|---|---|---|---|
| F344 rats | Stevioside | Decrease in mammary adenomas | [21] |
| MCF-7 | Steviol | G2/M arrest, ROS-mediated apoptosis (SRB Assay) |
[22] |
| Stevioside | G1 arrest, Bax overexpression, apoptosis (MTT Assay) |
[23] | |
| Hydroalcoholic extract | Increased cytotoxicity (MTT Assay) |
[36] | |
| Stevia extracts (various solvents) |
Increased cytotoxicity (SRB Assay) |
[32] | |
| ZnS Nanoparticles, aqueous extract | Increased cytotoxicity (MTT Assay) |
[42] | |
| Ammonium derivatives of steviol and isosteviol | Increased cytotoxicity (Multifunctional Cytell Cell Imaging system) |
[24] | |
| MCF-7, MDA * |
Aqueous extract | Decreased cell viability (MTT Assay) |
[37] |
| MDA-MB-231 | Steviolbioside | Cell proliferation inhibition (MTT Assay) |
[27] |
| Isosteviol Triazole Conjugates | Increased cytotoxicity (MTT Assay) |
[28] | |
| MDA-MB-231, SKBR3 |
Stevioside | Cell proliferation inhibition (MTT Assay) |
[25] |
* no further description.