Table 4.
Biological effects of S. rebaudiana in other types of cancer.
| Model/Cancer Type | Compound | Effect (Cell Viability Assay) |
Reference |
|---|---|---|---|
| A549 (Lung) |
Steviol, isosteviol derivatives |
Increased cytotoxicity (MTT Assay) |
[44] |
| Isosteviol Triazole Conjugates |
Increased cytotoxicity (MTT Assay) |
[28] | |
| Ammonium derivatives of steviol and isosteviol | Increased cytotoxicity (Multifunctional Cytell Cell Imaging system) |
[24] | |
| BALL1 (Leukemia) |
Stevioside and isosteviol derivatives | Increased cytotoxicity (MTT Assay) |
[45] |
| C-6 (Rat glioma) |
Flowering twigs essential oils | Increased cytotoxicity (SRB Assay) |
[67] |
| CHOK-1 (Chinese hamster ovary) |
Flowering twigs essential oil | Increased cytotoxicity (SRB Assay) |
[67] |
| HeLa (Cervix) |
Isosteviol Triazole Conjugates |
Increased cytotoxicity (MTT Assay) |
[28] |
| Stevioside and ethanolic extract | Increased cytotoxicity (MTT Assay) |
[46] | |
| Secondary metabolites from leaves (except luteolin) |
Increased cytotoxicity (MTT Assay) |
[60] | |
| Ammonium derivatives of steviol and isosteviol | Increased cytotoxicity (Multifunctional Cytell Cell Imaging system) |
[24] | |
| HL-60 (Leukemia) |
Steviol and isosteviol derivatives | Increased cytotoxicity and apoptosis (MTT Assay and Flow cytometry Analysis) |
[44] |
| Isosteviol Triazole conjugates |
Effect on cell proliferation (CellTiter-Glo® Luminescent Cell Viability Assay) |
[28] | |
| MOLT-4 (Leukemia) |
Stevioside and isosteviol derivatives | Increased cytotoxicity (MTT Assay) |
[45] |
| Isosteviol Triazole conjugates | Effect on cell proliferation (CellTiter-Glo® Luminescent Cell Viability Assay) |
[28] | |
| PC-3 (Prostate) |
Isosteviol Triazole Conjugates | Increased cytotoxicity (MTT Assay) |
[28] |
| Ammonium derivatives of steviol and isosteviol | Increased cytotoxicity (Multifunctional Cytell Cell Imaging system) |
[24] | |
| T98G (Glioblastoma) |
Ammonium derivatives of steviol and isosteviol | Increased cytotoxicity (Multifunctional Cytell Cell Imaging system) | [24] |
| U2OS (Osteosarcoma) |
Steviol | Increased cytotoxicity, G1 arrest apoptosis (MTT Assay and Flow Cytometry Analysis) |
[59] |
| Mouse skin papillomas | Stevioside, Rebaudiosides A and C and Dulcoside A | Tumor inhibition (TPA/DMBA-induced carcinogenesis) |
[56] |
| Steviol, Stevioside and Isosteviol | Tumor inhibition (TPA/DMBA-induced carcinogenesis) |
[57] |