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. 2022 Feb 17;15(2):241. doi: 10.3390/ph15020241

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ndfip1/2 were associated with AG1024 induced JAK1 diminishment. (A) The mRNA expression of either Ndfip1 (a) or Ndfip2 (b) were significantly depleted by gene silencing. The relative mRNA expression levels of Ndfip1 (a) or Ndfip2 (b) in ST cells harboring the respective Ndfip1-shRNA, Ndfip2-shRNA, or control shRNA are shown along with their respective quantitation as measured using semi-RT-PCR. (B) Depleting either Ndfip1 (a) or Ndfip2 (b) prevented the downregulation of the JAK1 protein level by AG1024 treatment. *, p < 0.05; **, p < 0.01. Results shown are averages ± SD from three independent experiments.