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. 2022 Feb 16;23(4):2170. doi: 10.3390/ijms23042170

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Fatty acid metabolism in the TME of ovarian cancer. Fatty acid-mediated lipid metabolism in TME is well controlled by cancer cells, adipocytes and stromal cells with complex processes, leading to ovarian cancer metastasis and drug resistance. CAF, cancer-associated fibroblast; NK cell, natural killer cell; TAM, tumor-associated fibroblast; DC, dendritic cell; SREBP-1, sterol regulatory element binding protein 1; FABP, fatty acid binding protein; FASN, fatty acid synthase; SIK2, salt-inducible kinase 2; MCP-1, monocyte chemoattractant protein-1; TIMP-1, tissue inhibitor of metalloproteinase-1; TGF-β1, transforming growth factor β1.