Table 2.
Mean value and hotspot volume for BBB permeability and 11C-PK11195 binding across the three groups
| Group |
ANCOVA result |
|||||
|---|---|---|---|---|---|---|
| Control | Sporadic SVD | CADASIL | SVD versus control | CADASIL versus control | ||
| BBB permeability | n = 19 | n = 19 | n = 19 | |||
| Mean Ki (×10−3 ml/g/min) | NAWM | 0.06 (0.06) | 0.50 (0.58) | 0.18 (0.29) |
F(1,34) = 15.34 P < 0.001 |
F(1,34) = 1.95 P = 0.34 |
| WMH | 0.04 (0.08) | 0.38 (0.52) | 0.08 (0.11) |
F(1,32) = 12.07 P = 0.003 |
F(1,32) = 1.34 P = 0.51 |
|
| Hotspot volume, % | NAWM | 2.78 (2.75) | 11.31 (9.50) | 5.60 (7.40) |
F(1,34) = 9.94 P = 0.007 |
F(1,34) = 0.63 P = 0.87 |
| WMH | 1.94 (2.52) | 11.14 (13.31) | 3.52 (4.47) |
F(1,32) = 11.59 P = 0.004 |
F(1,32) = 1.35 P = 0.51 |
|
| 11C-PK11195 binding | n = 17 | n = 16 | n = 14 | |||
| Mean BPND | NAWM | 0.04 (0.03) | 0.07 (0.07) | 0.06 (0.04) |
F(1,29) = 1.14 P = 0.59 |
F(1,27) = 1.05 P = 0.63 |
| WMH | 0.06 (0.12) | 0.01 (0.09) | 0.02 (0.05) |
F(1,27) = 0.67 P = 0.84 |
F(1,25) = 0.02 P = 1.00 |
|
| Hotspot volume, % | NAWM | 4.77 (2.89) | 11.02 (9.46) | 11.28 (11.65) |
F(1,29) = 12.48 P = 0.003 |
F(1,27) = 4.86 P = 0.07 |
| WMH | 0.63 (1.31) | 3.76 (5.95) | 2.18 (2.10) |
F(1,27) = 11.89 P = 0.004 |
F(1,25) = 20.52 P < 0.001 |
|
Values are presented as mean (SD). Significant P-values are shown in bold.