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Mefloquine enhances the anti-SARS-CoV-2 activity of remdesivir. Calu-3 cells were infected with SARS-CoV-2 at an MOI 0.1 for 1 h at 37 °C. Inoculum was removed and cells were treated with 1 or 2 µM of mefloquine combined with the indicated concentrations of remdesivir (RDV). Virus titers were measured by PFU/mL in the culture supernatants after 48 hpi. Results are displayed as the percentage of inhibition.
