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Mefloquine’s PBPK model predicted the plasma concentration for different dosages. Predicted mefloquine plasma concentration for 450 mg TID (A) or 350 mg QID (B) doses for 3 days. The dotted and the solid lines represent the EC90 values of mefloquine for SARS-CoV-2 in Vero E6 and Calu-3 cell types, respectively.
