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. 2022 Feb 11;13:813772. doi: 10.3389/fendo.2022.813772

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Copyright © 2022 Yang, Wang, Song, Xu, Chen, Tian, Zhang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The KEGG pathway analysis of the 27 potential therapeutic targets. (A) The 15 significant pathways. The bubbles’ sizes are indicated from big to small in descending order of the count of the potential targets enriched in the pathways. The bubbles’ colors are indicated from red to blue in descending order of -lg (p-value). (B) CoQ10-targets-pathways network. The width of the line is proportional to the number of connected points. (C) Module analysis of the target-pathway network. The diamond nodes represent the pathways, and the ellipse nodes represent the targets. The red nodes represent the hub genes obtained from the PPI network of potential therapeutic targets.