Figure 2.

Cox adjusted survival curves of ASNS-catalyzed asparagine. (A) OS of females, (B) OS of males, (C) RFS of females, and (D) RFS of males. Results were based on Model 2 (Table 2) using multivariate Cox PH regression, adjusted for anatomic location, chemotherapy history, clinical stages, age (continuous), and other crucial metabolites involved in ASNS-catalyzed asparagine synthesis (aspartate, glutamate, glutamine, and AMP were treated as continuous variables and were log₂ transformed). p values for the associations between dichotomized asparagine levels and the prognosis in Model 2.