. 2022 Feb 9;12(2):164. doi: 10.3390/metabo12020164

Table 2.

Multivariate analysis of asparagine synthesis catalyzed by asparagine synthetase (ASNS).

Prognosis	Sex	Model 1 ^a			Model 2 ^b
Prognosis	Sex	HR (95% CI) ^c	p	p _interaction ^d	HR (95% CI) ^c	p	p _interaction ^d
OS	Females	6.39 (1.78–22.91)	0.004	0.02	5.68 (1.06–30.61)	0.04	0.052
OS	Males	0.57 (0.36–0.91)	0.02	0.02	0.46 (0.11–1.84)	0.27	0.052
RFS	Females	4.36 (1.39–3.68)	0.01	0.003	4.89 (1.07–22.39)	0.04	0.03
RFS	Males	0.96 (0.61–1.50)	0.86	0.003	1.15 (0.27–4.80)	0.85	0.03

^a Asparagine abundance was considered as a continuous variable (log₂ transformed). ^b Asparagine abundance was dichotomized to low levels (≤75% percentile of asparagine abundance among all patients) (reference) and high levels (>75% percentile). ^c Hazard ratio for asparagine abundance in the corresponding multivariate Cox PH model, adjusted for anatomic location, clinical stages, chemotherapy history, age (continuous), and other crucial metabolites involved in ASNS-catalyzed asparagine synthesis (aspartate, glutamate, glutamine, and AMP were treated as continuous variables and were log₂ transformed). ^d p values for the interaction between sex and asparagine.