. 2022 Feb 9;12(2):164. doi: 10.3390/metabo12020164

Table A1.

Multivariate analyses of the associations between individual metabolites and 5-year OS by sex, using patients with complete information of KRAS mutation, BRAF mutation, and MSI status (N = 136, females = 67, males = 69).

Metabolite Name	Females			Males			Int. Sex p Value ^b
Metabolite Name	HR	95% CI	p Value ^a	HR	95% CI	p Value ^a	Int. Sex p Value ^b
Acetyl-lysine	1.06	0.76–1.49	0.735	0.57	0.42–0.78	<0.001	0.025
Adenosine	1.01	0.62–1.63	0.976	1.42	1.04–1.94	0.029	0.254
ADMA	1.58	0.90–2.78	0.109	0.51	0.33–0.80	0.003	0.002
Alanine	1.43	0.89–2.30	0.144	0.65	0.46–0.91	0.012	0.007
Arginine	1.70	0.72–4.03	0.227	0.53	0.28–0.99	0.045	0.049
Argininosuccinic acid	1.08	0.71–1.64	0.713	0.58	0.40–0.83	0.003	0.026
Citrulline	1.76	0.97–3.18	0.063	0.44	0.25–0.77	0.004	0.001
CMP	1.27	0.55–2.90	0.578	0.57	0.36–0.90	0.017	0.076
Glycerol 3-phosphate	4.20	1.24–14.25	0.021	1.03	0.39–2.74	0.948	0.057
GMP	1.13	0.62–2.07	0.686	0.59	0.39–0.89	0.013	0.055
Histidine	1.23	0.72–2.08	0.451	0.73	0.53–1.00	0.049	0.080
Lysine	1.54	0.63–3.74	0.341	0.54	0.30–0.98	0.044	0.030
LysoPC(16:0)	2.03	1.18–3.49	0.010	0.77	0.52–1.14	0.188	0.003
LysoPC(16:1)	1.13	0.69–1.86	0.632	0.67	0.45–0.98	0.038	0.088
Methionine	2.38	0.81–7.00	0.114	0.35	0.17–0.75	0.007	0.009
Ornithine	1.63	0.59–4.50	0.347	0.41	0.19–0.91	0.028	0.032
Phenylalanine	1.68	0.55–5.08	0.359	0.26	0.09–0.71	0.008	0.027
Serine	2.88	0.82–10.15	0.100	0.34	0.16–0.71	0.004	0.005
Spermine	2.13	1.29–3.52	0.003	1.16	0.82–1.63	0.407	0.076
Taurine	0.63	0.19–2.11	0.451	0.34	0.14–0.79	0.013	0.475
Threonine	1.38	0.62–3.08	0.432	0.39	0.20–0.75	0.005	0.012
Tyrosine	0.81	0.40–1.68	0.578	0.60	0.37–0.99	0.044	0.325
Uracil	2.87	0.70–11.76	0.143	0.30	0.16–0.58	<0.001	0.005
Xanthosine	1.21	0.85–1.73	0.288	0.56	0.37–0.84	0.006	0.016

^a p values for the association between individual metabolites and 5-year OS calculated by multivariate Cox PH regression models, adjusted for anatomic location, clinical stages, chemotherapy history, age, KRAS mutation, BRAF mutation, and MSI status (before FDR adjustment). The abundance of each metabolite was treated as a continuous variable and was log₂ transformed. A metabolite with HR < 1 was associated with better OS; a metabolite with HR > 1 was associated with worse OS. ^b p value of the interaction between the metabolite and sex. Int. Sex p value < 0.05 indicate a significant sex interaction.