Table 1.

The Global Heterozygous Prevalence of Risk Variants in the General Population.

Gene with Most Common Risk Allele	Global Heterozygous Prevalence (%)	Percent of Subjects with Variant *
Dopamine D2 Receptor (DRD2): ** rs1800497—risk allele A1	46	Asian 33%, Black or African American 55%, Hispanic or Latino 59%, Mixed Race 100%, Other 22%, Unknown 31%, White or Caucasian 34%
Dopamine D3 Receptor (DRD3): rs6280—risk allele C (Ser9Gly)	41	Asian 56%, Black or African American 93%, Hispanic or Latino 52%, Mixed Race 100%, Other 67%, Unknown 56%, White or Caucasian 54%
Dopamine D4 Receptor (DRD4): rs1800955—risk allele C (48bp repeat VNTR)	42	Asian 44%, Black or African American 57%, Hispanic or Latino 55%, Mixed Race 100%, Other 78%, Unknown 58%, White or Caucasian 70%
µ-Opioid Receptor (OPRM1): rs1799971—risk allele G (A118G)	29	Asian 56%, Black or African American 2%, Hispanic or Latino 28%, Mixed Race 0%, Other 0%, Unknown 39%, White or Caucasian 21%
Serotonin Transporter Receptor (5HTT) Linked Promoter Region (5HTTLPR) in SLC6A4: rs25531—risk allele S’	43 *	Asian 100%, Black or African American 71%, Hispanic or Latino 76%, Mixed Race 100%, Other 56%, Unknown 81%, White or Caucasian 76%

* Data derived from GARS tests of greater than 1000 subjects. ** An rs number is an accession number used by researchers and databases to refer to specific SNPs. It stands for Reference SNP cluster-ID.