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Molecular mechanisms of angiogenesis in activated endothelial cells. Ligand binding induces dimerization and autophosphorylation of tyrosine kinase receptors (VEGFR2, FGFRs, Tie-2). Receptor activation brings on the recruitment of several adaptor proteins that trigger signaling pathways leading to proliferation, migration, improved survival and loss of intercellular adhesions of endothelial cells.
