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. 2022 Feb 11;23(4):2012. doi: 10.3390/ijms23042012

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Nerve injury-induced TSLP expression in both small-sized and large-sized DRG neurons, esp. nociceptive DRG neurons. Distribution of TSLP was detected when DRG neurons were double-labeled (yellow) with TSLP (green) and neuronal markers (red). (A) Detection of peripherin presented as a small-sized neuronal marker and (B) NF200 as a large-sized neuronal marker. TSLP-positive DRG neurons expressed not only peripherin but also NF200 in the ipsilateral (ipsi) injured side as compared to that in the contralateral (contra) side and sham group. (C) Detection of substance P presented as a peptidergic non-myelinated neuronal marker and (D) TRPV1 as a nociceptive marker. TSLP-positive DRG neurons expressed TRPV1 mostly in the ipsilateral (ipsi) injured side as compared to that in the contralateral (contra) side and sham group. Pairs of merged images are shown on the right panel. White arrows indicate doubled-labeled cells. Scale bars represent 50 μm (n = 6 rats).