Table 4.

List of studies from the last 10 years investigating the effect of ART-type drugs related to necroptosis and pyroptosis in cancer cells with information on the model systems used, the ART-type drugs tested and the major findings of the study.

Cell Lines; Cancer	Drugs	Effects	Ref.
Necroptosis
Diverse cell lines	ATS	Cell viability↓; p-MLKL↑; RIPK1↑; Caspase inhibitor z-VAD-fmk (zVAD), Nec and siRIPK1 rescue ATS-induced cell death	2014 [115]
Diverse cell lines	ATS	Cell viability↓; ROS↑; Mitochondrial ROS↑; zVAD, Nec, siRIPK1, and ROS scavengers rescue ATS-induced cell death;	2017 [116]
MT-2, MT-4, HUT-102; Leukemia	ATS	T-cell growth↓; ROS↑; Nec rescues ATS-induced cell death; Tumor growth↓	2020 [78]
Pyroptosis
MCF-7, MDA-MB-231; Breast cancer	DHA	Cell viability↓; Colony formation↓; LDH↑; AIM2↑; Cleaved caspase 3↑; GSDME/DFNA5↑; HMFB1↑; IL-1β↑; shAIM2 and shDFNA5 restore cell survival and colony formation; Tumor growth↓	2021 [118]
Eca109, Ec9706; Esophageal squamous cell carcinoma	DHA	Cell viability↓; LDH↑; IL-1β↑; GSDME-NT↑; Cleaved caspase 3↑; Caspase inhibitor Ac-DEVD-CHO reduces GSDME-NT, LDH, IL-1β, and rescue cell viability; Tumor growth↓	2021 [119]

Arrow “↑” indicates an enhancing effect or upregulation; “↓” indicates a diminishing effect or downregulation.