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. 2022 Feb 3;12(2):143. doi: 10.3390/metabo12020143

Table 3.

Seminal parameters of the study cohort according to TyG index suggesting insulin resistance (N = 726).

Overall
(N = 726)
TyG Index < 8.1
(N = 387)
TyG Index ≥ 8.1
(N = 339)
p Value *
Idiopathic NOA [No. (%)] 147 (19.7) 63 (16.3) 84 (24.8) <0.001
Semen volume (mL) 0.8
Median (IQR) 3.0 (2–4) 3.0 (2–5) 3.0 (2–4)
Range 0.9–13.0 0.9–10.0 1.0–13.0
Sperm concentration 0.03
Median (IQR) 10.0 (2–29) 12.0 (2.8–30.0) 8.0 (1.5–25.0)
Range 0.5–455.3 0.5–305.9 0.5–455.3
Sperm concentration < 15 × 106/mL [No. (%)] 426 (58.6) 205 (52.9) 221 (65.1) 0.01
Progressive motility 0.4
Median (IQR) 21.0 (10–35) 21.0 (10–35) 20.0 (9–35)
Range 0.0–78.0 0.0–75.0 0.0–78.0
Progressive motility < 32% [No. (%)] 507 (69.8) 264 (68.2) 243 (71.6) 0.3
Normal morphology 0.2
Median (IQR) 2.0 (1–7) 2.0 (1–6) 2.0 (1–7)
Range 0.0–100 0.0–100.0 0.0–92.0
Normal morphology < 4% [No. (%)] 459 (63.2) 240 (62.0) 219 (64.6) 0.5
Number of sperm alterations [No. (%)] 0.2
0 66 (9.1) 39 (10.1) 27 (7.9)
1 188 (25.8) 109 (28.1) 79 (23.3)
2 225 (30.9) 115 (29.7) 110 (32.4)
3 247 (34.0) 124 (32.1) 123 (36.4)
Sperm DNA fragmentation (SDF) index 0.01
Median (IQR) 34.5 (21.2–51.7) 28.0 (18.5–48.5) 38.2 (23.1–53.7)
Range 0.4–99.8 0.4–97.7 0.4–99.8
SDF index > 30% [No. (%)] 403 (55.5) 188 (48.7) 215 (63.4) <0.01

Keys: TyG index = Triglycerides/glucose index; NOA = Non obstructive azoospermia; SDF = Sperm DNA fragmenta-tion index. * p value according to the Mann-Whitney test for continuous data and the Chi Square Test for categorical variables, as indicated.