TABLE 3.
RESULTS FROM STRESS TEST MODEL FOR LMD ADJUSTING FOR CLINICAL FACTORS
| Left main stenosis ≥ 50% | |||
|---|---|---|---|
| Clinical Variables | OR | 95% CI | P-value |
| Age at Enrolment, years 1 | <.001 | ||
| 65 versus 55 | 1.40 | 1.19 – 1.65 | |
| 75 versus 55 | 1.56 | 1.21 – 2.01 | |
| Female Sex among nuclear modality | 0.26 | 0.14 – 0.48 | <.001 |
| Race/Ethnicity | 0.489 | ||
| Non-Hispanic White | ref | ||
| Non-Hispanic Asian | 1.01 | 0.74 – 1.37 | |
| Other | 0.84 | 0.62 – 1.14 | |
| Hypertension | 0.95 | 0.75 – 1.2 | 0.681 |
| Diabetes | 0.87 | 0.70 – 1.09 | 0.217 |
| Cigarette Smoking | 0.36 | ||
| Never Smoked | ref | ||
| Former Smoker | 0.84 | 0.66 – 1.07 | |
| Current Smoker | 0.97 | 0.67 – 1.35 | |
| Prior MI | 0.61 | 0.42 – 0.88 | 0.009 |
| eGFR (ml/min)1 | 0.977 | ||
| 60 versus 120 | 1.03 | 0.74 – 1.43 | |
| 90 versus 120 | 1.00 | 0.78 – 1.27 | |
| Stress Test Variables | |||
| Number of ischemic segments on stress echo, per 1 segment increase | 1.10 | 0.96 – 1.25 | 0.158 |
| Number of infarcted segments on stress echo, per 1 segment increase | 1.08 | 0.94 – 1.25 | 0.268 |
| Summed difference score on nuclear ≥ 10 | 1.49 | 0.95 – 2.33 | 0.080 |
| Summed stress score on nuclear | 1.00 | 0.96 – 1.04 | 0.977 |
| TID (Transient ischemic dilation in the LV) on nuclear | 1.01 | 0.63 – 1.62 | 0.965 |
| TID (Transient ischemic dilation in the LV) on stress echo | 1.63 | 1 – 2.66 | 0.049 |
| Maximum ST Depression in Any Lead on ETT, per 1 mm increase | 1.28 | 1.08 – 1.52 | 0.004 |
| Peak exercise METs on ETT 3 | <.001 | ||
| Peak exercise METs up to 5 | 0.82 | 0.58 – 1.17 | |
| Peak exercise METs above 5 | 0.74 | 0.63 – 0.86 | |
| Severe or Moderate Anterior Ischemia on nuclear | 1.32 | 0.91 – 1.92 | 0.141 |
| Severe or Moderate Anterior Ischemia on stress echo | 1.04 | 0.58 – 1.84 | 0.904 |
| LAD + LCX ischemia on nuclear | 1.32 | 0.76 – 2.32 | 0.327 |
| LAD + LCX ischemia on stress echo | 1.24 | 0.69 – 2.22 | 0.475 |
1
Modeled as a restricted cubic spline.
2
Note: There is a sex by modality interaction term in model. The odds ratios for modality by sex are not presented in this table due to the modality specific covariates.
The sex by modality interaction p-value in LM>= 50% model is: 0.15
3
Modeled as a linear spline.
Cindex for Left main stenosis ≥ 50%: 0.684
Joint test for Imaging and Stress Test variables is: <.001
ETT = exercise tolerance testing (non-imaging); METs = metabolic equivalents achieved during stress testing