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. 2022 Feb 13;14(2):406. doi: 10.3390/pharmaceutics14020406

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Tissue structure for stavudine solution (A) and stavudine-AuNP (B). C_{i_v} and C_{i_ev}, stavudine vascular and extravascular concentration of each tissue; $C_{i_v}^{n p}$ and $C_{i_e v}^{n p}$ stavudine-AuNP vascular and extravascular concentration of each tissue; $K_{u p_{i}}$ , AuNP uptake rate constant estimated of each tissue; P_i and $P_{i}^{n p}$ , partition coefficient of each tissue with and without nanoparticles; PS_i and $P S_{i}^{n p}$ permeability-surface area coefficient of each tissue with and without nanoparticles; Q_i, blood flow of of each tissue; V_{i_v} and V_{i_ev}, vascular and extravascular volume of each tissue.