Table 2.
Biological term enrichment analysis of the 135 miR-183 candidate direct target genes.
| Wikipathways | ||
|---|---|---|
| Term | Adjusted p-Value | Genes |
| EGF/EGFR Signaling Pathway WP437 | 3.59 × 10−5 | MAP3K2;MAPK7;GRB2;PTPN11;IQGAP1;CBL;CRK;SOS2;AP2M1;EGFR |
| Focal Adhesion WP306 | 4.92 × 10−5 | ITGB1;CCND1;PIK3CA;CTNNB1;GRB2;ARHGAP5;CRK;ACTB;RHOA;EGFR;VEGFA |
| RAC1/PAK1/p38/MMP2 Pathway WP3303 | 5.91 × 10−5 | ITGB1;PIK3CA;CTNNB1;PTPN11;GRB2;CRK;EGFR |
| VEGFA-VEGFR2 Signaling Pathway WP3888 | 7.15 × 10−5 | ITGB1;CCND1;PIK3CA;CTNNB1;GRB2;PTPN11;IQGAP1;CBL;CRK;RHOA;VEGFA |
| Regulation of Actin Cytoskeleton WP51 | 7.80 × 10−5 | PIK3CA;RDX;IQGAP1;CRK;SOS2;ACTB;RHOA;EGFR;SSH1 |
| Signaling of Hepatocyte Growth Factor Receptor WP313 | 1.82 × 10−4 | ITGB1;PIK3CA;PTPN11;GRB2;CRK |
| MET in type 1 papillary renal cell carcinoma WP4205 | 1.92 × 10−4 | PIK3CA;PTPN11;GRB2;CBL;SOS2;CRK |
| ErbB Signaling Pathway WP673 | 2.17 × 10−4 | CCND1;PIK3CA;GRB2;CBL;SOS2;CRK;EGFR |
| Endometrial cancer WP4155 | 2.20 × 10−4 | CCND1;PIK3CA;CTNNB1;GRB2;SOS2;EGFR |
| ESC Pluripotency Pathways WP3931 | 5.93 × 10−4 | MAPK7;LRP5;CTNNB1;GRB2;PTPN11;IL6ST;EGFR |
| KEGG | ||
| Proteoglycans in cancer | 2.75 × 10−8 | ITGB1;RDX;PTPN11;IQGAP1;CBL;ACTB;RHOA;EGFR;VEGFA;CCND1;PIK3CA;CTNNB1;GRB2;SOS2P |
| Focal adhesion | 1.65 × 10−6 | ITGB1;CCND1;PIK3CA;CTNNB1;GRB2;ARHGAP5;CRK;SOS2;ACTB;RHOA;EGFR;VEGFA |
| Human cytomegalovirus infection | 4.31 × 10−6 | AKAP13;CCND1;PIK3CA;GNA11;CREB3L2;CTNNB1;GRB2;CRK;SOS2;RHOA;EGFR;VEGFA |
| Chronic myeloid leukemia | 4.99 × 10−5 | CCND1;PIK3CA;PTPN11;GRB2;CBL;SOS2;CRK |
| Bacterial invasion of epithelial cells | 5.19 × 10−5 | ITGB1;PIK3CA;CTNNB1;CBL;CRK;ACTB;RHOA |
| Regulation of actin cytoskeleton | 8.63 × 10−5 | ITGB1;PIK3CA;RDX;IQGAP1;CRK;SOS2;ACTB;RHOA;EGFR;SSH1 |
| Colorectal cancer | 9.66 × 10−5 | CCND1;PIK3CA;CTNNB1;GRB2;SOS2;RHOA;EGFR |
| Endometrial cancer | 9.88 × 10−5 | CCND1;PIK3CA;CTNNB1;GRB2;SOS2;EGFR |
| Prostate cancer | 1.45 × 10−4 | CCND1;PIK3CA;CREB3L2;CTNNB1;GRB2;SOS2;EGFR |
| Renal cell carcinoma | 2.20 × 10−4 | PIK3CA;PTPN11;GRB2;SOS2;CRK;VEGFA |
| GO Cellular Component | ||
| Focal adhesion (GO:0005925) | 6.05 × 10−5 | NUP214;ITGB1;RDX;ADAM10;IQGAP1;LPP;ACTB;RHOA;EGFR;SENP1;MPRIP;ANXA6;CTNNB1;SNTB2 |